Young patient with choroidal melanoma
a clinical case report
DOI:
https://doi.org/10.70313/2718.7446.v17.n02.329Keywords:
choroidal melanoma, fundus, acute glaucoma, enucleationAbstract
We describe the clinical case of a 34-year-old male patient who consulted the Ophthalmology Emergency Room of the HIGA Rodolfo Rossi, due to pain and right red eye of 48 hours of evolution, diagnosed in another center with acute glaucoma. A complete ophthalmologic examination showed a severe decrease in visual acuity of the right eye associated with moderate ciliary injection, epithelial corneal edema, narrow anterior chamber, arreactive pupil, Tyndall + and increased intraocular pressure, without involvement of the other eye. The right fundus was not visible due to media opacity and no dilation. Ultrasound of the right eye showed a lobulated image in the posterior pole with optic nerve involvement, of medium reflectivity, 14.5 mm high and 10.5 mm wide, with choroidal excavation, compatible with choroidal melanoma. The left eye had no alterations. The Oncology Department was consulted to rule out metastasis and it was decided to perform right eye enucleation with prosthesis placement. The anatomopathologic result reported atypical neoplastic proliferation of pigmented spindle cells, compatible with choroidal melanoma. The importance of the case, beyond the particular youth of the patient with ocular tumor, lies in highlighting the multiple forms of clinical presentation of choroidal melanoma, as well as the fact that it is essential to check the eye fundus in all patients. This will allow early detection of cases that may be initially asymptomatic, in order to perform a prompt treatment to improve the patient’s life expectancy.
Downloads
References
Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 1998; 83: 1664-1678.
Singh AD, Turell ME, Topham AK. Uveal melanoma: trends in incidence, treatment, and survival. Ophthalmology 2011; 118: 1881-1885.
Prescher G, Bornfeld N, Hirche H et al. Prognostic implications of monosomy 3 in uveal melanoma. Lancet 1996; 347: 1222-1225.
Guénel P, Laforest L, Cyr D et al. Occupational risk factors, ultraviolet radiation, and ocular melanoma: a case-control study in France. Cancer Causes Control 2001; 12: 451-459.
Holly EA, Aston DA, Ahn DK, Smith AH. Intraocular melanoma linked to occupations and chemical exposures. Epidemiology 1996; 7: 55-61.
Donoso LA, Folberg R, Naids R et al. Metastatic uveal melanoma. Hepatic metastasis identified by hybridoma-secreted monoclonal antibody MAb8-1H. Arch Ophthalmol 1985; 103: 799-801.
Diener-West M, Reynolds SM, Collaborative Ocular Melanoma Study Group et al. Development of metastatic disease after enrollment in the COMS trials for treatment of choroidal melanoma: Collaborative Ocular Melanoma Study Group report No. 26. Arch Ophthalmol 2005; 123: 1639-1643.
Kujala E, Mäkitie T, Kivelä T. Very long-term prognosis of patients with malignant uveal melanoma. Invest Ophthalmol Vis Sci 2003; 44: 4651-4659.
McLean IW, Foster WD, Zimmerman LE. Uveal melanoma: location, size, cell type, and enucleation as risk factors in metastasis. Hum Pathol 1982; 13: 123-132.
Shields CL, Ganguly A, Bianciotto CG et al. Prognosis of uveal melanoma in 500 cases using genetic testing of fine-needle aspiration biopsy specimens. Ophthalmology 2011; 118: 396-401.
Harbour JW. The genetics of uveal melanoma: an emerging framework for targeted therapy. Pigment Cell Melanoma Res 2012; 25: 171-181.
Sisley K, Rennie IG, Parsons MA et al. Abnormalities of chromosomes 3 and 8 in posterior uveal melanoma correlate with prognosis. Genes Chromosomes Cancer 1997; 19: 22-28.
Shields CL, Manalac J, Das C et al. Choroidal melanoma: clinical features, classification, and top 10 pseudomelanomas. Curr Opin Ophthalmol 2014; 25: 177-185.
Shields CL, Cater J, Shields JA et al. Combination of clinical factors predictive of growth of small choroidal melanocytic tumors. Arch Ophthalmol 2000; 118: 360-364.
Semenova E, Finger PT. Palladium-103 radiation therapy for small choroidal melanoma. Ophthalmology 2013; 120: 2353-2357.
Shields CL, Shields JA, De Potter P et al. Diffuse choroidal melanoma: clinical features predictive of metastasis. Arch Ophthalmol 1996; 114: 956-963.
Shields CL, Pellegrini M, Kligman BE et al. Ciliary body and choroidal pseudomelanoma from ultrasonographic imaging of hypermature cataract in 20 cases. Ophthalmology 2013; 120: 2546-2551.
Seider MI, Damato BE. Imaging the intraocular tumor. Expert Rev Ophthalmol 2014; 9: 387-399.
Medina CA, Singh AD. Imaging of intraocular tumors: proper imaging studies can be the key to diagnosis. Retinal Physician 2014; 11: 19-25.
Collaborative Ocular Melanoma Study (COMS). Accuracy of diagnosis of choroidal melanomas in the Collaborative Ocular Melanoma Study. COMS report no. 1. Arch Ophthalmol 1990; 108: 1268-1273.
Tailor TD, Gupta D, Dalley RW et al. Orbital neoplasms in adults: clinical, radiologic, and pathologic review. Radiographics 2013; 33: 1739-1758.
Papastefanou VP, Islam S, Szyszko T et al. Metabolic activity of primary uveal melanoma on PET/CT scan and its relationship with monosomy 3 and other prognostic factors. Br J Ophthalmol 2014; 98: 1659-1665.
Shields JA, Mashayekhi A, Ra S, Shields CL. Pseudomelanomas of the posterior uveal tract: the 2006 Taylor R. Smith Lecture. Retina 2005; 25: 767-771.
Shields CL, Demirci H, Materin MA et al. Clinical factors in the identification of small choroidal melanoma. Can J Ophthalmol 2004; 39: 351-357.
U.S. National Cancer Institute (NCI). Physician Data Query (PDQ). Intraocular (uveal) melanoma treatment [en línea]. Bethesda: NCI, 2019. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK65836/
Komatsu T, Sowa T, Takahashi K, Fujinaga T. A case of solitary pulmonary metastasis of choroidal melanoma with an exceptionally long disease-free period. Int J Surg Case Rep 2013; 4: 849-851.
Damato B, Hope-Stone L, Cooper B et al. Patient-reported outcomes and quality of life after treatment of choroidal melanoma: a comparison of enucleation versus radiotherapy in 1596 patients. Am J Ophthalmol 2018; 193: 230‐251.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Consejo Argentino de Oftalmología

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Con esta licencia no se permite un uso comercial de la obra original, ni la generación de obras derivadas. Las licencias Creative Commons permiten a los autores compartir y liberar sus obras en forma legal y segura.