Didanosine retinal toxicity

Abstract

Objectives: We report long-term follow-up for a didanosine-associated retinal toxicity (DART) case, demonstrating its progression once didanosine (DDI) administration was discontinued under multimodal imaging. We propose this case to enrich the literature on retinal DDI toxicity through diagnosis and to understand the fundamental role in multimodal retinal imaging for detection and monitoring of retinal toxicity.
Case description: A 69-year-old man with a loss of night vision and complained of slowly progressive peripheral field of vision constriction over the past 7 years. His visual acuity was 20/20 in the right eye and 25/20 in the left eye. The patient was identified with fundoscopy and multimodal imaging that showed bilateral retinal alterations in the mid-periphery well-delineated zones of RPE atrophy associated with relative loss of neurosensory retina and choriocapillaris. There was a progression of retinopathy during follow-up after 7 years since DDI was discontinued.
Conclusion: DART is a progressive disorder despite drug session. The use of multimodal images of the fundus and functional testing in patients with DDI toxicity allows a more precise study of their progression and study of the findings in these patients.