Valores normales de los parámetros de tomografía de coherencia óptica en niños y adolescentes sanos
DOI:
https://doi.org/10.70313/2718.7446.v18.n2.416Keywords:
optical coherence tomography, normal values, ocular parameters, OCT, children, adolescentsAbstract
Objective: To determine the normality values of optical coherence tomography (OCT) parameters in pediatric population in Venezuela.
Materials and methods: A descriptive, cross-sectional study was performed, including 100 healthy participants (200 eyes) between 7 and 17 years of age, who attended the Hospital Central Universitario “Dr. Antonio María Pineda”, between March and July 2024. Spectral domain OCT was used, evaluating nerve fiber layer thickness (NLC), ganglion cell complex (GCC) and macular thickness. Data description and comparison between sexes and right and left eyes were performed.
Results: Mean age was 11.07 ± 2.60 years, 70% were between 7-12 years old and 52% were female. The thickness of the CFN did not show statistical differences between right and left eyes, but for temporal thickness there were differences (p <0.05). Macular thickness for both eyes were similar, as well as for GCC. NFC thickness, macular thickness and GCC thickness by eye and sex did not show statistically significant differences. There were differences in macular volume being higher in males and in both eyes (p <0.05). The three parameters were similar for the 7-12 years and 13-17 years groups.
Conclusions: Normality data were described for our population of 7 and 17 year olds, of both sexes, using spectral domain OCT, hoping that it may be useful as a reference for future pathology determination.
Downloads
References
1. Huang D, Swanson EA, Lin CP et al. Optical coherence tomography. Science 1991; 254(5035): 1178-1181. doi:10.1126/science.1957169.
2. Yang L, Chen P, Wen X, Zhao Q. Optical coherence tomography (OCT) and OCT angiography: technological development and applications in brain science. Theranostics 2025; 15(1): 122-140. doi:10.7150/thno.97192.
3. Banc A, Ungureanu MI. Normative data for optical coherence tomography in children: a systematic review. Eye (Lond) 2021; 35(3): 714-738. doi:10.1038/s41433-020-01177-3.
4. Nemeș-Drăgan IA, Drăgan AM, Hapca MC, Oaida M. Retinal nerve fiber layer imaging with two different spectral domain optical coherence tomographs: normative data for Romanian children. Diagnostics (Basel) 2023; 13(8): 1377. doi:10.3390/diagnostics13081377.
5. Pua TS, Hairol MI. Evaluating retinal thickness classification in children: a comparison between pediatric and adult optical coherence tomography databases. PLoS One 2024; 19(12): e0314395. doi:10.1371/journal.pone.0314395.
6. Asefzadeh B, Cavallerano AA, Fisch BM. Racial differences in macular thickness in healthy eyes. Optom Vis Sci 2007; 84(10): 941-945. doi:10.1097/OPX.0b013e318157a6a0.
7. Verkicharla PK, Suheimat M, Schmid KL, Atchison DA. Differences in retinal shape between East Asian and Caucasian eyes. Ophthalmic Physiol Opt 2017; 37(3): 275-283. doi:10.1111/opo.12359.
8. Bowd C, Zangwill LM, Weinreb RN et al. Racial differences in rate of change of spectral-domain optical coherence tomography-measured minimum rim width and retinal nerve fiber layer thickness. Am J Ophthalmol 2018; 196: 154-164. doi:10.1016/j.ajo.2018.08.050.
9. KhalafAllah MT, Zangwill LM, Proudfoot J et al. Racial differences in diagnostic accuracy of retinal nerve fiber layer thickness in primary open-angle glaucoma. Am J Ophthalmol 2024; 259: 7-14. doi:10.1016/j.ajo.2023.10.012.
10. Laotaweerungsawat S, Psaras C, Haq Z, Liu X, Stewart JM. Racial and ethnic differences in foveal avascular zone in diabetic and nondiabetic eyes revealed by optical coherence tomography angiography. PLoS One 2021; 16(10): e0258848. doi:10.1371/journal.pone.0258848.
11. Wolf P, Larsson E, Åkerblom H. Normative data and repeatability for macular ganglion cell layer thickness in healthy Swedish children using swept source optical coherence tomography. BMC Ophthalmol 2022; 22(1): 109. doi:10.1186/s12886-022-02321-1.
12. Muñoz-Gallego A, De la Cruz J, Rodríguez-Salgado M et al. Interobserver reproducibility and interocular symmetry of the macular ganglion cell complex: assessment in healthy children using optical coherence tomography. BMC Ophthalmol 2020; 20(1): 197. doi:10.1186/s12886-020-01379-z.
13. Del-Prado-Sánchez C, Seijas-Leal O, Gili-Manzanaro P, Ferreiro-López J, Yangüela-Rodilla J, Arias-Puente A. Choroidal, macular and ganglion cell layer thickness assessment in Caucasian children measured with spectral domain optical coherence tomography. Eur J Ophthalmol 2021; 31(6): 3372-3378. doi:10.1177/1120672120965486.
14. Al-Haddad C, Barikian A, Jaroudi M, Massoud V, Tamim H, Noureddin B. Spectral domain optical coherence tomography in children: normative data and biometric correlations. BMC Ophthalmol 2014; 14: 53. doi:10.1186/1471-2415-14-53.
15. Jammal HM, Al-Omari R, Khader Y. Normative data of macular thickness using spectral domain optical coherence tomography for healthy Jordanian children. Clin Ophthalmol 2022; 16: 3571-3580. doi:10.2147/OPTH.S386946.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Consejo Argentino de Oftalmología
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Con esta licencia no se permite un uso comercial de la obra original, ni la generación de obras derivadas. Las licencias Creative Commons permiten a los autores compartir y liberar sus obras en forma legal y segura.
How to Cite
