Síndrome de la superficie ocular permeable

Alejandro Aguilar; Fernanda Girado

doi:10.70313/2718.7446.v17.n02.319

Autores

Alejandro Aguilar Departamento de Superficie Ocular, Grupo Médico Las Lomas, San Isidro, Buenos Aires, Argentina
Fernanda Girado Departamento de Superficie Ocular, Hospital Policial Churruca Visca, Buenos Aires, Argentina

DOI:

https://doi.org/10.70313/2718.7446.v17.n02.319

Palavras-chave:

intestino permeável, inflamação, autoimunidade, câncer, superfície ocular, córnea, conjuntiva, alergia, olho seco, toxicidade, superfície ocular permeável, conjuntiva patente

Resumo

Há muito se reconhece que a permeabilidade intestinal é alterada quando as junções estreitas entre as células epiteliais não regulam corretamente o transporte transcelular de macromoléculas, o que pode causar uma interação entre os antígenos dos microrganismos que habitam o lúmen intestinal e o sistema imunológico do hóspede. Esta perda da função de barreira intestinal aumenta a sua permeabilidade e pode desencadear fenómenos inflamatórios, autoimunes e até tumorais. Fatores genéticos, clima, dieta, estresse agudo e crônico, condições e hábitos socioeconômicos e a microbiota estão ligados a essa alteração. Diferentes autores apontam o aumento da permeabilidade intestinal e seu impacto nos pulmões, na pele e no cérebro, motivando a descrição dos eixos intestino-pulmão, intestino-pele e intestino-cérebro. Seguindo esta linha descritiva postulamos nossa hipótese pessoal sobre a possível manifestação de um eixo intestino-superfície ocular. Da mesma forma, e dado que tanto o intestino como a conjuntiva são mucosas com barreiras epiteliais, propomos o potencial para a superfície ocular (principalmente à custa da conjuntiva) se comportar como o intestino, e no caso da perda devido à sua permeabilidade pode desencadear os fenômenos inflamatórios, autoimunes e tumorais mencionados acima.

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