Síndrome da superfície ocular permeável
DOI:
https://doi.org/10.70313/2718.7446.v17.n02.319Palavras-chave:
intestino permeável, inflamação, autoimunidade, câncer, superfície ocular, córnea, conjuntiva, alergia, olho seco, toxicidade, superfície ocular permeável, conjuntiva patenteResumo
Há muito se reconhece que a permeabilidade intestinal é alterada quando as junções estreitas entre as células epiteliais não regulam corretamente o transporte transcelular de macromoléculas, o que pode causar uma interação entre os antígenos dos microrganismos que habitam o lúmen intestinal e o sistema imunológico do hóspede. Esta perda da função de barreira intestinal aumenta a sua permeabilidade e pode desencadear fenómenos inflamatórios, autoimunes e até tumorais. Fatores genéticos, clima, dieta, estresse agudo e crônico, condições e hábitos socioeconômicos e a microbiota estão ligados a essa alteração. Diferentes autores apontam o aumento da permeabilidade intestinal e seu impacto nos pulmões, na pele e no cérebro, motivando a descrição dos eixos intestino-pulmão, intestino-pele e intestino-cérebro. Seguindo esta linha descritiva postulamos nossa hipótese pessoal sobre a possível manifestação de um eixo intestino-superfície ocular. Da mesma forma, e dado que tanto o intestino como a conjuntiva são mucosas com barreiras epiteliais, propomos o potencial para a superfície ocular (principalmente à custa da conjuntiva) se comportar como o intestino, e no caso da perda devido à sua permeabilidade pode desencadear os fenômenos inflamatórios, autoimunes e tumorais mencionados acima.
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